Is uncured pepperoni safe to eat? (Natural curing)

In this brief article, we are going to answer the question “Is uncured pepperoni safe to eat?” We also will discuss the main differences between cured and uncured pepperoni. 

Is uncured pepperoni safe to eat?

Yes,  uncured pepperoni is safe to eat. The terminology and labeling surrounding uncured meat products can be quite perplexing and remain partially unresolved, particularly when it comes to the concept of “alternative curing.” In this category, the inclusion of purified nitrite or nitrate salts is not permitted, but naturally occurring sources of these chemicals are acceptable.

The primary issue lies in a separate regulation established by the USDA, which necessitates labeling traditionally cured meat products as “uncured” if purified nitrate and nitrite additives are omitted. This requirement only applies to products like frankfurters, bacon, corned beef, pastrami, and pepperoni. (1)

What is the difference between cured and uncured pepperoni?

Uncured meat products replicate the qualities of traditionally cured counterparts by employing natural curing ingredients derived from vegetables. These products can achieve cured meat quality and maintain food safety characteristics that are comparable to, and often indistinguishable from, those found in conventionally cured meat products.

The technology has evolved from early options that exclusively used nitrate to now include widely adopted pre-converted nitrite alternatives.

These modern alternatives have ingredient concentrations that allow for minimal to no discernible impact on quality, making them suitable for direct replacement at the same maximum concentrations traditionally used with purified versions.

Uncured products exhibit similar size, flavor, texture, and overall appearance as products that are typically prepared with nitrate, nitrite, or a combination of both. (1)

How is meat cured?

Curing techniques rely on various components, including salt (sodium chloride), sodium nitrate­, nitrite, and substances with reducing prope­rties. The central role­ in meat curing is played by sodium nitrite.

As a ve­rsatile chemical catalyst, it induces the formation of nitric oxide compounds that give cured meat products their characteristic color. Sodium nitrite also e­nhances flavors, inhibits oxidative reactions, and effectively hinders the growth of pathogenic microorganisms. (2)

What are the health implications of salt-cured meat?

The potential health risks associated with nitrite in cured meats, as well as its potential connection to human exposure to N-nitroso compounds, have been extensively studied and debated in the realm of research.

It’s important to note that nitrate and nitrite demonstrate toxicity levels significantly higher than those typically found in cured meats. Lethal oral doses for humans fall within the range of 80–800 mg of nitrate per kg of body weight and 33–250 mg of nitrite per kg of body weight.

These quantities far exceed the controlled concentrations found in cured meats. Moreover, inadvertent increases in nitrate and nitrite levels in cured meats can be easily prevented by using salt-nitrite and dye-curing mixtures.

However, beyond mere toxicity concerns, there is the potential formation of carcinogenic N-nitrosamines. This formation occurs through the interaction of nitrous acid with secondary amines during the cooking process of cured meats. (3)

Is uncured pepperoni a healthier alternative?

No, there’s likely little health advantage to be gained by choosing uncured pepperoni over its cured counterpart. Modern meat processing techniques have evolved to the point where nitrate and nitrite can be indirectly incorporated into these products, achieving characteristics typical of cured pepperoni.

Many processors employing “natural curing” methods follow processing procedures that, for the most part, resemble those involving chemical nitrites and nitrates.

Naturally-cured products typically rely on natural sources of nitrate, but it’s worth noting that some natural ingredients may also contain nitrite. If a consistent supply of nitrite is available from a natural source, there is usually no need to alter the standard processing methods. (4)

What is the role of natural ingredients in uncured pepperoni?

Uncured pepperoni commonly incorporates natural ingredients, with sea salt being the most prominent. While sea salt has been suggested as a potential nitrate source, available analytical data indicates that its nitrate content is relatively low.

The second most prevalent ingredient is raw sugar, typically in the form of turbinado sugar. Turbinado sugar is a raw sugar derived from the evaporation of sugar cane juice, followed by centrifugation to remove surface molasses.

Natural flavorings, spices, celery juice, or celery juice concentrate are often listed ingredients, and since these are of plant/vegetable origin, they can significantly contribute to the nitrate content. 

Additional ingredients that can be considered as curing adjuncts for natural or organic processed meats include vinegar, lemon juice solids, and cherry powder. Cherry powder, used in uncured pepperoni, is notably rich in ascorbic acid, which acts as a potent nitrite reductant. Rosemary, a natural antioxidant, can be employed to safeguard the flavor and inhibit lipid oxidation in processed meats. (4)

How can pepperoni be naturally cured?

For naturally-cured meat products, like pepperoni, that rely on natural ingredients as their nitrate source, it is essential to use an ingredient with a relatively high natural nitrate content. The nitrate­ ion offers higher availability, greater concentration consistency, and increased stability compared to nitrite.

When using a natural nitrate­ source, it is necessary to conve­rt nitrate to nitrite. A crucial component of this process is the use of a nitrate-re­ducing bacterial culture to achieve typical cured pepperoni prope­rties.

Meat curing has long recognized the importance of bacteria re­ducing nitrate to nitrite, and commercial culture­s have been available­ for many years. In all natural curing processes, it is essential to evenly distribute­ the nitrate source and the starter culture for consistent curing results. (4)


In this brief article, we answered the question “Is uncured pepperoni safe to eat?” We also discussed the main differences between cured and uncured pepperoni. In my research, I was able to point out that there is very little difference between the cured and uncured pepperoni. In my perspective, as a food scientist, uncured pepperoni is as safe as regular pepperoni. 

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SEBRANEK, Joseph G.; BACUS, James N. Cured meat products without direct addition of nitrate or nitrite: what are the issues?. Meat science, v. 77, n. 1, p. 136-147, 2007.